Martin Blomberg Jensen

Developing novel treatment for management of menopausal symptoms and complications

Applicant

Martin Blomberg Jensen

Project description

Hormonal replacement therapy is the only therapy for menopausal symptoms and complications but carries unwanted side effects. Other treatments can be used for complications e.g., Semaglutide for weight gain and bisphosphonates/Denosumab for osteoporosis.

We have human and animal data showing that high serum levels of Luteinizing hormone, which is a hallmark of peri- and menopause and treatment, are implicated in temperature regulation, menopausal weight gain, and osteoporosis. By pharmacological inhibition of LH activity in a menopausal mouse model, we aim to establish proof of concept for this novel idea. The SPARK program enables us to produce LH inhibitors in sufficient quantity to conduct large-scale de-risking proof of concept studies.

Institution

Herlev-Gentofte Hospital